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GDS-80 is invented upon patented aerodynamic theory to utilize a supersonic gas flow generated by the pressure difference between the inside and the outside pressures of the gas chamber, in the barrel to accelerate the bio-particles to 300m/sec by low pressure Helium gas or 200m/sec by Nitrogen gas. GDS-80 can be widely used in the fields of gene therapy, gene transient or stable expression research, agriculture biotechnology research, vaccine research, and immune research. It is a highly efficient and convenient gene transfection tool to deliver not only micro carrier-coated samples for plant applications but also naked DNA samples for animal applications. Furthermore, due to the low pressure is used to drive the particle into the cells, it even brings less cell damages and minimum noise.